Know (of)
Examiner
Do you know anyone who is popular?
Candidate
Yes, Tom Cruise.
Well, if you are a friend of Tom Cruise, then OK. But if you have never even met Tom Cruise then you might know of him, but you probably don't know him.
Know - without 'of'
If you know someone, then they also know you:
- you meet them either regularly or occasionally
- you know quite a lot about them
(you probably know where they live) - they know quite a lot about you
(they probably know where you live)
Know of
If you know of someone, then they probably do not know you.
- you have never met them
- they have never met you
- if you know aything about them, this is probably because..
- you have read about them
- you have seen them in the media
- other people told you about them
The following would be more appropriate:
Examiner
Do you know anyone who is popular?
Candidate
Yes, my sister is popular. Everybody likes her. She's so kind to everyone.